Linked Michaelis-Menten type models for
methanogenesis data
Technical details and software relevant to
the report
“A stable isotope titration method for measurement of
the contribution of acetate and carbon dioxide reduction to methane production”
By N.D. Gray, J.N.S. Matthews and I.M. Head
The above report discusses
the fitting of a Michaelis-Menten model to the rate of production of 13CH4
produced in anaerobic microcosms titrated with varying amounts of 13C
labelled substrate, together with a linked model for the amount of 12CH4
also produced. This page gives access to some details of the technical
statistical issues behind the method and also provides a program for fitting
the model.
The program is the same one
that was used to calculate the estimates in the above report. It has been
checked carefully for this purpose with this dataset. No guarantee is
given regarding the correctness of the answers the program produces. The
FORTRAN code may be modified by the user as they wish. While the authors
would be grateful to hear of any genuine errors users believe they have
encountered, they give no undertaking to be able to fix these and cannot give
advice on amendment or development of the software.