Statistical Method for Estimating Cerebral Blood Flow
using the Kety-Schmidt Technique
The paper "A statistical method for the estimation of cerebral blood flow
using the Kety-Schmidt technique" (Matthews, JNS, Matthews, DSF, and Eyre,
JA, Clinical Science, 1999, 97, 485-492)
proposes a statistical method for estimating the cerebral blood flow from
data on the arterial and venous concentrations of an inert marker, nitrous
oxide, using the method of Kety and Schmidt. A program for the PC
to fit the statistical model proposed is available from this page.
KS_ARCH.EXE, which can be obtained by clicking here
, is a self-extracting .ZIP archive containing: programs to fit model I
(see above paper) and to find profile likelihood intervals for cerebral
blood flow; a short manual (three versions, Word, text and PDF formats)
and example data and log files. The manual can be viewed without
downloading the other files by clicking here .
It is suggested that you download KS_ARCH.EXE to an empty directory
and run the archive, for example by double-clicking on it in Windows Explorer.
The programs run in a DOS box under Windows 95 but will also run under
MS-DOS or Windows 3.1. The program has modest memory requirements
and any Pentium chip or 486 DX chip will run the programs. The minimum
requirement is actually a 386 processor + 387 co-processor.
The program has been used extensively by our research group and appears
to work correctly. However, no liability is accepted for the use
of the program or its consequences.
J.N.S. Matthews