Hi Tim, Phil, sorry it's taken so long to get back in touch. Having now looked through your Minitab file, I think I slightly misunderstood the nature of the problem initially. I suggested a Friedman test to simultaneously check for significant differences in treatment results between your different time "windows" and your two groups; however, a Friedman test should only be used if your two groups are realted in some way. Considering each of sCr and CrC, this is what I would do: 1) To check for differences in renal function through time, compare